Acta Med.Scand. 1972 Oct;192(4):293-298.
Five patients with hereditary angioneurotic oedema (HANE) have been treated, in a random double-blind cross-over study, with tranexamic acid (trans-AMCHA). Three patients have reacted positively to the treatment. The positive effect in these cases has been so obvious that a specific effect of trans-AMCHA seems probable even if it cannot be definitely ruled out that spontaneous variations have been the cause of this effect. Therapeutic trials with fibrinolytic inhibitors should be made on patients with HANE.
Available online at: http://onlinelibrary.wiley.com/doi/10.1111/j.0954-6820.1972.tb04818.x/abstract (small fee)