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The Icatibant Outcome Survey: Treatment of laryngeal angioedema attacks

OBJECTIVE: To characterize the management and outcomes of life-threatening laryngeal attacks of hereditary angioedema (HAE) treated with icatibant in the observational Icatibant Outcome Survey (NCT01034969) registry.

METHODS: This retrospective analysis was based on data from patients with HAE type I/II who received healthcare professional-administered or self-administered icatibant to treat laryngeal attacks between September 2008 and May 2013.

RESULTS: Twenty centers in seven countries contributed data. Overall, 42 patients with HAE experienced 67 icatibant-treated laryngeal attacks. Icatibant was self-administered for 62.3% of attacks (healthcare professional-administered, 37.7%). One icatibant injection was used for 87.9% of attacks, with rescue or concomitant medication used for 9.0%. The median time to treatment was 2.0h (n=31 attacks) and the median time to resolution was 6.0h (n=35 attacks).

CONCLUSIONS: This analysis describes successful use of icatibant for the treatment of laryngeal HAE attacks in a real-world setting.

Available from: https://journals.lww.com/euro-emergencymed/Fulltext/2016/06000/The_Icatibant_Outcome_Survey___treatment_of.13.aspx

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